南京農(nóng)業(yè)大學(xué)工學(xué)院導(dǎo)師信息：馮治洋 正文

姓名： 馮治洋 學(xué)歷： 
職稱(chēng)： 教授 職務(wù)： 
部門(mén)： 生物工程 郵件： zfeng@njau.edu.cn
辦公電話： 025-84399511 辦公地址： 食品院205
研究方向： 微生物宏基因組學(xué)、天然產(chǎn)物生物合成

　　
教學(xué)情況：
　　主持研究生課程<生物技術(shù)藥物進(jìn)展>
　　
科研情況：
　　2006 年博士畢業(yè)于日本名古屋大學(xué),2006年至2012年先后在美國(guó)威斯康星大學(xué)麥迪遜分校和洛克菲勒大學(xué)做博士后研究，2012年受聘為南京農(nóng)業(yè)大學(xué)食品科技學(xué)院教授。已在PNAS, JACS等期刊上發(fā)表SCI論文15篇。
　　Huang SX﹟, Feng Z﹟, Wang L﹟, Galm U, Wendt-Pienkowski E, Yang D, Tao M, Coughlin JM, Duan Y, Shen B (2012) A designer bleomycin with significantly improved DNA cleavage activity. J Am Chem Soc, 134:13501-13509. (﹟ co-first author)
　　Feng Z, Chakraborty D, Dewell S, Reddy BV, Brady SF (2012) Environmental DNA encoded antibiotics fasamycin A and B inhibit FabF in type II fatty-acid biosynthesis. J Am Chem Soc, 134:2981–2987.
　　Iqbal HA, Feng Z, Brady SF (2012) Biocatalysts and small molecule products from metagenomic studies. Curr Opin Chem Biol, 16:109-16.
　　Reddy BV, Kallifidas D, Kim JH, Charlop-Powers Z, Feng Z, Brady SF (2012) Natural product biosynthetic gene diversity in geographically distinct soil microbiomes. Appl Environ Microbiol, 78:3744-52.
　　Feng Z, Kallifidas D, Brady SF (2011) Functional analysis of environmental DNA-derived Type II polyketide synthases reveals structurally diverse secondary metabolites. Proc Natl Acad Sci USA, 108:12629-12634.
　　Biggins JB, Liu X, Feng Z, Brady SF. (2011) Metabolites from the Induced Expression of Cryptic Single Operons Found in the Genome of Burkholderia pseudomallei. J Am Chem Soc, 133:1638-1641.
　　Yang D, Zhu X, Wu X, Feng Z, Huang L, Shen B, Xu Z. (2011) Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR. Appl Microbiol Biotechnol, 89:1709-1719.
　　Feng Z, Kim JH, Brady SF (2010) Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster. J Am Chem Soc, 132:11902-11903.
　　Kim JH, Feng Z, Bauer JD, Kallifidas D, Calle PY, Brady SF. (2010) Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR. Biopolymers, 93:833-844.
　　Wu X, Yang D, Zhu X, Feng Z, Lv Z, Zhang Y, Shen B, Xu Z. (2010) Iso-migrastatin Titer Improvement in the Engineered Streptomyces lividans SB11002 Strain by Optimization of Fermentation Conditions. Biotechnol Bioprocess Eng, 15:664-669.
　　Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B. (2009) iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. J Biol Chem, 284:29746-29756.
　　Feng Z, Wang L, Rajski SR, Xu Z, Coeffet-LeGal MF, Shen B (2009) Engineered production of iso-migrastatin in heterologous Streptomyces hosts. Bioorg Med Chem, 17:2147-2153.

南京農(nóng)業(yè)大學(xué)

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