大連醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院導(dǎo)師：秘曉林 正文

[導(dǎo)師姓名]
秘曉林

[所屬院校]
大連醫(yī)科大學(xué)

[基本信息]
導(dǎo)師姓名：秘曉林
性別：
人氣指數(shù)：1230
所屬院校：大連醫(yī)科大學(xué)
所屬院系：基礎(chǔ)醫(yī)學(xué)院
職稱：教授
導(dǎo)師類(lèi)型：博導(dǎo)
招生專業(yè)：
研究領(lǐng)域：1.DNA損傷導(dǎo)致的細(xì)胞周期調(diào)節(jié)、凋亡、轉(zhuǎn)錄調(diào)控的機(jī)制；2.非編碼RNA（miRNA和ln...

[通訊方式]
辦公電話：0411-86110513
電子郵件：xl2000bi@163.com

[個(gè)人簡(jiǎn)述]
秘曉林，博士，教授，博士生導(dǎo)師。
大連醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院副院長(zhǎng)，生物科學(xué)系主任。入選中國(guó)科學(xué) 院“引進(jìn)國(guó)外杰出人才--百人計(jì)劃”，遼寧省“攀登學(xué)者”。國(guó)家科技
獎(jiǎng)、國(guó)家重大科學(xué)研究計(jì)劃、自然科學(xué)基金、博士后科學(xué)基金、美 國(guó)國(guó)家科學(xué)基金研究生項(xiàng)目等評(píng)議人，SCI雜志International Journal of Nanomedicine顧問(wèn)編委，Journal of Biochemistry and Molecular Biology Research編委，中國(guó)生化藥物雜志編委，中國(guó)環(huán)境誘變劑學(xué) 會(huì)理事，Biomaterials、Genetics、Environmental Toxicology and Pharmacology、International Journal of Nanomedicine、PLoS One等 雜志審稿人。主持國(guó)家重點(diǎn)基礎(chǔ)研究計(jì)劃“973”項(xiàng)目課題、自然科 學(xué)基金面上項(xiàng)目、中國(guó)科學(xué)院創(chuàng)新項(xiàng)目等。 1990年畢業(yè)于蘭州大學(xué)，獲生物化學(xué)學(xué)士學(xué)位。1996年畢業(yè)于衛(wèi)生 部蘭州生物制品研究所，獲免疫學(xué)和微生物學(xué)碩士學(xué)位。1999年畢
業(yè)于中國(guó)預(yù)防醫(yī)學(xué)科學(xué)院病毒學(xué)研究所，獲病原生物學(xué)博士學(xué)位。 同年赴美國(guó)，在國(guó)立衛(wèi)生研究院（National Institutes of Health）癌 癥研究所（National Cancer Institute）從事博士后研究，隨后任職美
國(guó)國(guó)立衛(wèi)生研究院癌癥研究所高級(jí)研究學(xué)者。作為通訊作者，研究 成果發(fā)表在Proceedings of National Academy of Sciences USA, Oncogene, Human Molecular Genetics, Biomaterials, Journal of Cell Science, Nanotoxicology等國(guó)際一流學(xué)術(shù)期刊。

[科研工作]
代表性文章（*通訊作者）
1. Li D., Liu Y., Pei C., Zhang P., Pan L., Xiao J., Meng S., Yuan Z., Bi X. *A miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proceedings of National Academy of Sciences USA. 2017. (In press) IF 9.4
2. Cong W., Wang P., Qu Y., Tang J., Bai R., Zhao Y., Chen C. , Bi X. * Evalutation of the influence of Fullerenol on aging and stress resistance using Caenorhabditis elegans. Biomaterials. 2015. 42:78-86. IF 8.6 3. Jiang K., Liu M., Lin G., Mao B., Cheng W., Liu H., Gal J., Zhu H., Yuan Z., Deng W., Liu Q., Gong P., Bi X. *, Meng S. * Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. Oncotarget. 2016. 7 (18): 25652-25667. IF 5.0 4. Qian X., Wang P., Xia Y., Dou T., Jin Q., Wang D., Hao D., Bi X. *, Ge G. *, Yang L.* A highly selective fluorescent probe for sensing activities of catechol-O-methyltransferase in complex biological samples. Sensors and Actuators B. 2016. 231:615–623. IF 4.8 5. Chen H., Wang B., Feng W., Du W., Ouyang H., Chai Z., Bi X.* Oral Magnetite Nanoparticles Disturb the Development of Drosophila Melanogaster from Oogenesis to Adult Emergence. Nanotoxicology. 2015. 9(3):302-312. IF 7.9 6. Yuan Q., Han J., Cong W., Ge Y., Ma D., Dai Z., Li Y., Bi X. * Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced myelosuppression toxicity. International Journal of Nanomedicine. 2014. 9(1): 4829-4846. IF 4.3 7. Fang G., Zhang D., Yin H., Zheng L., Bi X.*, Yuan L.* Centlein maintains centrosome cohesion by bridging an interaction between C-Nap1 and Cep68. Journal of Cell Science. 2014. 127:1631-1639. IF 5.4 8. Wang Y., Wang Z., Joshi BH., Puri R., Stultz B., Yuan Q., Bai Y., Zhou P., Yuan Z., Hursh DA., Bi X.* The tumor suppressor Caliban regulates DNA damage induced apoptosis through p53-dependent and –independent activity. Oncogene. 2013. 32(33):3857-66. IF 8.6 9. Liu W., Jiang F., Bi X.*, Zhang Q*. Drosophila FMRP participates in DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Human Molecular Genetics. 2012, 21(21):4655-68. IF 7.7 10. Kong L., Yuan Y., Zhu H., Li Y., Guo Q., Zhao Y., Wang Q., Bi X.*, Gao X*. The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis. Biomaterials. 2011.32(27)：6515-6522. IF 7.6 11. Wang P., Bai Y., Song B., Wang Y., Liu D., Lai Y., Bi X.*, Yuan Z*. PP1A-mediated dephosphorylation positively regulates YAP2 activity. PLoS ONE. 2011.6(9):e24288. IF 4.3 12. Gao G., Bi X., Chen J., Srikanta D., Rong YS. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Proc. Nat. Acad. Sci. USA. 2009. 106(26): 10728–10733.(Equal contribution). IF 9.4 13. Bi X., Jones T., Abbasi F., Lee H., Stultz B., Hursh D., Mortin M. Drosophila Caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Oncogene. 2005. 24:8229-8239. IF 6.8 14. Bi X., Srikanta D., Fanti L., Pimpinelli S., Badugu R., Kellum R., Rong Y.S. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc. Nat. Acad. Sci. USA. 2005. 102(42):15167-15172. IF 10.2 15. Bi X., Gong M., Srikanta D., Rong Y.S. Drophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. Genetics. 2005. 171:845-847. IF 4.4 16. Bi X., Wei S.D., Rong Y.S. Telomere protection without a telomerase: the role of ATM and Mre11 in Drosophila telomere maintenance. Current Biology. 2004. 14:1348-1353. IF 11.9 17. Bi X., Kajava A., Demidenko Z., Jones T., Mortin M. The carboxyl terminus of Prospero regulates its subcellular localization. Molecular and Cellular Biology. 2003. 23 (3): 1014-1024. IF 8.9

[教育背景]

大連醫(yī)科大學(xué)

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