寧波大學(xué)醫(yī)學(xué)院導(dǎo)師：徐淑君

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寧波大學(xué)醫(yī)學(xué)院導(dǎo)師：徐淑君正文

[導(dǎo)師姓名]
徐淑君

[所屬院校]
寧波大學(xué)

[基本信息]
導(dǎo)師姓名：徐淑君
性別：女
人氣指數(shù)：3334
所屬院校：寧波大學(xué)
所屬院系：醫(yī)學(xué)院
職稱：副教授
導(dǎo)師類型：
招生專業(yè)：生物化學(xué)與分子生物學(xué)
研究領(lǐng)域：神經(jīng)生物

[通訊方式]
辦公電話：0574-87609594
電子郵件：xushujun@nbu.edu.cn
通訊地址：寧波江北風(fēng)華路818號(hào)寧波大學(xué)醫(yī)學(xué)院王長(zhǎng)來(lái)樓409

[個(gè)人簡(jiǎn)述]
徐淑君，女，博士，寧波大學(xué)醫(yī)學(xué)院行為神經(jīng)科學(xué)研究中心副教授，斯坦福醫(yī)學(xué)院分子和細(xì)胞生理系訪問(wèn)學(xué)者。浙江省神經(jīng)科學(xué)學(xué)會(huì)理事，浙江省神經(jīng)科學(xué)學(xué)會(huì)細(xì)胞和分子生物學(xué)委員會(huì)副主任委員，美國(guó)神經(jīng)科學(xué)學(xué)會(huì)（SocietyofNeuroscience），中國(guó)神經(jīng)科學(xué)學(xué)會(huì)，中國(guó)生理科學(xué)會(huì)會(huì)員。近年來(lái)一直從事神經(jīng)科學(xué)方面的研究。相關(guān)研究成果獲得省市等各類科研成果獎(jiǎng)6項(xiàng)，發(fā)表論文23篇，其中SCI收錄論文20篇，包括Molecular Neurobiology(IF: 6.19), hippocampus(IF: 5.17)、Journal of Alzheimers Disease(IF: 3.61)、Neuroscience(IF: 3.38)等雜志。文章總被引用次數(shù)達(dá)100多次。發(fā)表的論文被Trends in Neurosciences（影響因子為13.3）、Progress in Lipid Research（影響因子為9.5）、Neurobiology of Disease（影響因子為5.1）等國(guó)際著名期刊上的文章引用。曾擔(dān)任Journal of Alzheimers disease編委，是該雜志、Molecular Neurobiology、Neuroscience Bulletin、Progress in Biochemistry and Biophysics等雜志的審稿人。先后主持國(guó)家自然科學(xué)基金一項(xiàng)(30900430)，浙江省自然科學(xué)基金兩項(xiàng)(LY12H09001，LY16H09001)，市自然科學(xué)基金三項(xiàng)(2011A610065, 2009A610119，2014A610258)，浙江省教育廳項(xiàng)目一項(xiàng)(Y200803366)、市人才項(xiàng)目一項(xiàng)（領(lǐng)軍和拔尖人才）。主要獲獎(jiǎng)情況：
[1]浙江省科技論文二等獎(jiǎng)：Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in culturedhippocampal neurons. 排名第一。
[2]寧波大學(xué)青年學(xué)術(shù)創(chuàng)新三等獎(jiǎng)：神經(jīng)退行性疾病發(fā)病機(jī)制的研究。排名第一。
[3]寧波市自然科學(xué)優(yōu)秀論文獎(jiǎng)：海馬神經(jīng)元突觸囊泡數(shù)目的多少和釋放模式。排名第一。
[4]浙江省科技進(jìn)步二等獎(jiǎng)：阿爾茨海默氏癥中β淀粉樣蛋白調(diào)節(jié)突出可塑性的機(jī)制研究。排名第三。
[5]寧波市科技進(jìn)步一等獎(jiǎng)（2011）：老年癡呆癥的病理機(jī)制及治療技術(shù)研究。排名第四。
聯(lián)系電話：0574-87609594, 15888592742. 郵箱： xushujun@nbu.edu.cn。

[科研工作]
[1]Shujun Xu#, Guilan Liu, Xiaoming Bao, Jie Wu, Shaomin Li, Bangxu Zheng, Roger Anwyl, Qinwen Wang(2014). Rosiglitazone prevents amyloid-β oligomer-induced impairment of synapse formation and plasticity via increasing dendrite and spine mitochondrial number.Journal ofAlzheimer’s Disease, 39(2):239-251. (#Corresponding author)
[2]Liting Jiang, Meng Huang,Shujun Xu#, Yu Wang, Pengyuan An, Chenxi Feng, Xiaowei Chen, Xiaofei Wei, Yifan Han, Qinwen Wang(2016). Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway.Molecular Neurobiology. 53:3832–3841(#Corresponding author)
[3]Shujun Xu, Qiao Guan, Chuang Wang,Xiaofei Wei, Xiaowei Chen,Junfang Zhang, Lan Chang,Wenhua Zhou, Istvan Mody,Qinwen Wang(2014).Rosiglitazone prevents the memory deficits induced by amyloid-beta oligomers via inhibition of inflammatory responses.Neuroscience Letters, 578(2014):7-11.
[4]Shujun Xu, Suya Zhou, Di Xia, Gang Chen, Shumin Duan, Jianhong Luo (2010).Defects of synaptic vesicle turnover at excitatory and inhibitory synapse in niemann-pick C1 deficient neurons.Neuroscience,167(2010): 608–620
[5]Suya Zhou, Shujun Xu*, Yinggang Yan, Huimei Yu, Shucai Ling, Jianhong Luo(2011).Decreased Purinergic Inhibition of Synaptic Activity in a Mouse Modelof Niemann-Pick Disease Type C. Hippocampus, 21(2011):212-219 (*Co-first author).
[6]Shujun Xu#,Xiaowei Chen, Xiaofei Wei, Guilan Liu, Qinwen Wang (2011). Presynaptic impairment in Niemann-Pick C1-deficient neurons: Not dependenton presence of glial cells. Neuroscience Letters,496(2011),54-59.(#Corresponding author)
[7]Bangxu Zheng, Pengyuan An, Liting Jiang, Yiyi Zheng, Qinwen Wang, Shujun Xu#(2015). Progress on the Mechanism of Intracellular Degradation ofβ-Amyloid Protein.Chinese Journal of Cell Biology, 37(5): 753–758. (#Corresponding author)
[8]LinLu, Shujun Xu#, Qinwen Wang(2012). The Relationship Between Astrocyte-mediated Metabolism ofβ-AmyloidProtein and Pathogenesis of the Early Stages of Alzheimer’s Disease.Progress in Biochemistry and Biophysics, 39(8): 715~720. (#Corresponding author)
[9]Guilan Liu, Xiaoming Bao, ZhouyiLu, Shujun Xu#, Qinwen Wang(2012).The Effect of Rosiglitazone on The DendriticDevelopment of Hippocampal Neurons.Progress in Biochemistry and Biophysics, 39(6): 574~580. (#Corresponding author)
[10]Shujun Xu,Guilan Liu (2011). Recent Progress of Mitochondrial Dysfunction Induced byβ-Amyloid Protein. Progress in Biochemistry and Biophysics, 37(6): 589~593.
[11]Shujun Xu, Ping Wang, Di Xia(2009). Quantitative analysis of synaptic vesicle release and readily releasablepool size in hippocampal neurons.Acta Physiologica Sinica, 61 (6): 505-510
[12]Shujun Xu,Wei Ning, Zhengping Xu, Suya Zhou, Huai Chiang, Jianhong Luo (2006).Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in culturedhippocampal neurons. Neuroscience Letters,398(2006),253-257.
[13]Shujun Xu, Zhong Chen, Lijun Zhu, Haiqing Shen, Jianhong Luo (2005).Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats. Acta Pharmacologia Sinica,26(2005),177-180.
[14]Wei Ning,Shujun Xu,Huai Chiang, Zhengping Xu, Suya Zhou, Jianhong Luo (2007). Effects of GSM 1800-MHz on dendritic development of hippocampal neurons in Culture. Acta Pharmacologia Sinica,28(2007),1873-1880.
[15]Lan Chang, Wei Cui,Yong Yang, Shujun Xu, Wenhua Zhou, Hongjun Fu,Shengquan Hu, Shinghung Mak, Juwei Hu, Qin Wang, VictorPui-YanMa, Tony Chung-lit Choi, Edmond Dik-lung Ma, Liang Tao, Yuanping Pang, Michael J. Rowan, Roger Anwyl, Yifan Han, Qinwen Wang(2015).Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Scientific Report,5(2015):10256.
[16]Xiaowei Chen,JuweiHu, Liting Jiang, Shujun Xu, Zhengping Xu, Chuang Wang, Junfang Zhang,Xiaofei Wei, Lan Chang, Qinwen Wang(2014).Brilliant Blue G improves cognition in an animal model of Alzheimer's disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons.Neuroscience,279(2014):94-101.
[17]Lan Chang, Fushun Li, Xiaowei Chen, Shujun Xu,Chuang Wang, Hongzhuan Chen, Qinwen Wang(2014).Effects of acidic oligosaccharide sugar chain on amyloid oligomer-induced impairment of synaptic plasticity in rats.MetabolicBrain Disease,29(3):683-690.
[18]Yinggang Yan, Jie Zhang, Shujun Xu,Jianhong Luo, Shuang Qiu, Wei Wang(2014). Clustering of surface NMDA receptors is mainly mediated by theC-terminus of GluN2A in cultured rat hippocampal neurons.Neuroscience Bulletin,30(4): 655–666.
[19]Xiaowei Chen,Ruyi Lin, Lan Chang, Shujun Xu,, Xiaofei Wei, Junfang Zhang,Chuang Wang, Roger Anwyl, Qinwen Wang(2013).Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3.Neuroscience,253(2013):435-43
[20]Xiaofei Wei,Yanghui Zhang, Lulu Zhang, Shujun Xu, Xiaowei Chen, Chuang Wang,Qianjun Si, Ketao Ma, Qinwen Wang(2013). CCK-8S increases the firing frequency of CCK-positive neurons and facilitates excitatory synaptic transmission in primary rat hippocampal neurons.Neuroscience Letters, 549(2013):34-39.
[21]Lulu Zhang,Xiaofei Wei,Yanghui Zhang,Shujun Xu, Xiaowei Chen, Chuang Wang,Qinwen Wang(2013). CCK-8S increased the filopodia and spines density in cultured hippocampal neurons of APP/PS1 and wild-type mice.Neuroscience Letters,542(2013):47-52.
[22]Fushun Li,Xiaowei Chen, Feiming Wang, Shujun Xu,Lan Chang, Roger Anwyl, Qinwen Wang(2013).Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption.Neural Regenernation Research,8(1):49-55.
[23]Lijun Jun, Zhong Chen, Lishan Zhang, Shujun Xu,Ajing Xu, Jianhong Luo(2004).Spatiotemporal changes of the N-methyl-D-aspartate receptor subunit levels in rats with pentylenetetrazole-induced seizures. Neuroscience Letters,356(2004):53-56.
浙江省神經(jīng)科學(xué)學(xué)會(huì)理事，浙江省神經(jīng)科學(xué)學(xué)會(huì)細(xì)胞和分子生物學(xué)委員會(huì)副主任委員
主持國(guó)家自然科學(xué)基金項(xiàng)目“NPC1蛋白突變對(duì)突觸形成和突觸功能的影響及其機(jī)制研究”, 浙江省自然科學(xué)基金項(xiàng)目“膠質(zhì)細(xì)胞溶酶體介導(dǎo)的阿爾茨海默病發(fā)病機(jī)制研究”及“鈣敏感受體在阿爾茨海默病中的作用及其機(jī)制研究”，寧波市自然科學(xué)基金項(xiàng)目“羅格列酮對(duì)阿爾茨海默病突觸功能損傷的保護(hù)作用及其機(jī)制研究”, 浙江省教育廳項(xiàng)目項(xiàng)目“β淀粉樣蛋白釋放機(jī)制的研究”，寧波市領(lǐng)軍和創(chuàng)新人才項(xiàng)目等

[教育背景]
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