寧波大學(xué)海洋學(xué)院導(dǎo)師:李成華
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寧波大學(xué)海洋學(xué)院導(dǎo)師:李成華 正文
[導(dǎo)師姓名]李成華
[所屬院校]
寧波大學(xué)
[基本信息]
導(dǎo)師姓名:李成華
性別:男
人氣指數(shù):6048
所屬院校:寧波大學(xué)
所屬院系:海洋學(xué)院
職稱:研究員
導(dǎo)師類型:
招生專業(yè):海洋生物學(xué)、生物化學(xué)與分子生物學(xué)、水產(chǎn)養(yǎng)殖、漁業(yè)資源、漁業(yè)發(fā)展
研究領(lǐng)域:水產(chǎn)動物免疫生物學(xué)
[通訊方式]
電子郵件:lichenghua@nbu.edu.cn
[個人簡述]
李成華,1978年9月生,博士,研究員,博士生導(dǎo)師,中國海洋與湖沼學(xué)會棘皮動物分會理事,浙江省動物學(xué)會理事,兼副秘書長。先后獲得中國水產(chǎn)學(xué)會首屆青年科技獎(2016年);浙江省151第二層次培養(yǎng)人員(2016年);國家優(yōu)秀青年科學(xué)基金(2015年),寧波市領(lǐng)軍和拔尖人才工程第一層次(2015年),浙江省杰出青年科學(xué)基金(2014年),浙江省高等學(xué)校中青年學(xué)科帶頭人(2013年)等人才工程資助。主持國家自然科學(xué)基金4項、浙江省杰出青年科學(xué)基金和浙江省科技廳國際合作項目等科研項目。目前主要從事海洋生物分子免疫學(xué)、病害防治和分子設(shè)計育種等方面的研究工作,在刺參免疫相關(guān)miRNA發(fā)掘和功能研究 以及病原微生物治病機制領(lǐng)域取得重要進展。以第一作者或通訊作者在“Frontiers in Immunology(IF3=6.062)”"Genetics(IF3=5.054)"、“Scientific Reports(IF3=5.022)”、"Journal of Hazardous Materials (IF3=5.143)"、“Developmental & Comparative Immunology(IF3=3.218)”等期刊發(fā)表SCI論文80余篇,個人H指數(shù)26;獲得授權(quán)發(fā)明專利4項;指導(dǎo)研究生獲得國家獎學(xué)金9人次(4年)。
[科研工作]
2010年以前:
(1)Li C., Song L*., Zhao J., Zou H., Su J., Zhang H. Genomic organization, nucleotide sequence analysis of the core histone genes cluster in Chlamys farreri and molecular evolution assessment of the H2A and H2B. DNA Sequence. 2006 17(6): 440-451.(IF=0.569)
(2)Li C., Song L*., Zhao J., Zhu L., Zou H., Zhang H., Wang H., Cai Z. The preliminary study on a potential antibacterial peptide derived from histone H2A in hemocytes of scallop Chlamys farreri. Fish Shellfish Immunol. 2007, 22 (6): 663-672. (IF=3.160)
(3)Li C., Zhao J., Song L*., Mu C., Zhang H., Gai Y., Qiu L., Yu Y., Ni D., Xing K. Molecular cloning, characterization, expression and functional analysis of an anti-lipopolysaccharide factor from Chinese mitten crab Eriocheir sinensis. Dev Comp Immunol. 2008, 32(7):784-794.(IF=2.833)
(4)Li C., Ni D., Song L*., Zhao J., Zhang H. Li L. Molecular cloning and characterization of a catalase from Zhikong scallop Chlamys farreri. Fish Shellfish Immunol. 2008, 24 (1): 27-34.(IF=3.160)
(5)Li C*., Zhao J., Song L*. A review of advances in research on marine molluscan antimicrobial peptides and their potential application in aquaculture. Molluscan Res. 2009, 29(1):17-26.(Invited Review). (共同通訊作者)(IF=0.583)
2010年:
(1)Zhao J., Li C*., Chen A., Li L., Su X., Li T. Molecular characterization of a novel big defensin from clam Venerupis philippinarum. PLoS One. 2010, 5(10):e13480. (通訊作者) (IF=4.411)
(2)Li C., Wang L., Ning X., Chen A., Zhang L., Qin S., Wu H., Zhao J*. Identification two small heat shock proteins with different response profile to environmental stresses in Venerupis philippinarum. Cell Stress Chaperon. 2010, 15(6): 897-904. (IF=3.162)
(3)Zhao J., Qiu L., Ning X., Chen A., Wu H., Li C*. Cloning and characterization of an Invertebrate type lysozyme from Venerupis philippinarum. Comp Biochem Phys B 2010, 156: 56-60. (通訊作者) (IF=1.989)
(4)Li C*., Zhang H., Li L., Song L*. Identification of a cathepsin D potentially involved in H2A cleavage from scallop Chlamys farreri. Mol Biol Rep. 2010, 37(3): 1451-1460. (共同通訊作者)(IF=1.875)
(5) Li C., Qiu L., Ning X., Chen A., Qin S., Wu H., Zhao J*. The first molluscan TCTP in Venerupis philippinarum: molecular cloning and expression analysis. Fish Shellfish Immunol. 2010, 29(9): 530-533.(IF=3.044)
(6)Li C., Sun H., Chen A., Ning X., Wu H., Qin S., Xue Q., Zhao J*. Identification and characterization of an intracellular Cu, Zn-superoxide dismutase (icCuZnSOD) gene from clam Venerupis philippinarum. Fish Shellfish Immunol. 2010, 28: 499-503. (IF=3.044)
2011年:
(1)Jin C., Li C*., Su X., Li T. Identification and characterization of a Tegillarca granosa ferritin regulated by iron ion exposure and thermal stress. Dev Comp Immunol. 2011, 35:745-751. (通訊作者) (IF=3.268)
(2)Li C*., He J., Su X., Li T. A manganese superoxide dismutases in blood clam Tegillarca granosa: molecular cloning, tissues distribution and expression analysis. Comp Biochem Phys B 2011, 159:64-70. (通訊作者)(IF=1.923)
(3)Li C., Li H., Su X., Li T*. Identification and characterization of a clam ferritin from Sinonovacula constricta. Fish Shellfish Immunol. 2011, 30:1147-1151 (IF=3.322)
(4)Li C., Li L., Liu F., Ning X., Chen A., Zhang L., Wu H., Zhao J*. Alternation of Venerupis philippinarum Hsp40 gene expression in response to pathogen challenge and heavy metal exposure. Fish Shellfish Immunol. 2011, 30(1):447-450.(IF=3.322)
(5)Zhang L., Zhao J., Li C*., Su X., Chen A., Li T., Qin S. Cloning and characterization of allograft inflammatory factor-1 (AIF-1) from manila clam Venerupis philippinarum. Fish Shellfish Immunol. 2011, 30(1): 148-153. (通訊作者). (IF=3.322)
(6)Li C*., Yu S., Zhao J., Su X., Li T. Cloning and characterization of a sialic acid binding lectins (SABL) from Manila clam Venerupis philippinarum. Fish Shellfish Immunol. 2011, 30:1202-1206. (通訊作者)(IF=3.322)
(7)李成華,崔靜,李曄,周君,蘇秀榕,李太武*。南移養(yǎng)殖仿刺參(Stichopus japonicus Selenka)鐵蛋白基因的克隆機表達特征分析。海洋與湖沼。2011,42(7):567-572.
2012年:
(1)Li C., Li Z., Li Y., Zhou J., Zhang C., Su X*., Li T. A ferritin from Dendrorhynchus zhejiangensis with heavy metals detoxification activity. Plos ONE. 2012, 7(12):e51428.(IF=3.73)
(2)Li C*., Su X*., Li Y., Li T., Sun C., Zhou T., Liu H. Two classes of glutathione S-transferase genes with different response pro?les to bacterial challenge in Venerupis philippinarum. Fish Shellfish Immunol. 2012, 32(1):219-222. (共同通訊作者)(IF=2.964)
(3)Li C*., Feng W., Qiu L., Xia C., Su X*., Jin C., Zou T., Zeng Y., Li T. Characterization of skin ulceration syndrome associated microRNAs in sea cucumber Apostichopus japonicus by deep sequencing. Fish Shellfish Immunol. 2012,33(2):436-441. (共同通訊作者) (IF=2.964)
(4)Li C., Ying Q., Su X*., Li T. Development and application of reverse transcription loop-mediated isothermal amplification for detecting live Shewanella putrefaciens in preserved fish sample. J Food Sci 2012, 77(4):M226-M230(IF=1.775)
(5)Li C*., Su X*., Wang M., Li Y., Li Y., Zhou J., Li T. Alteration of Phascolosoma esculenta heat shock protein 90 expression under heavy metal exposure and thermal stress. Genet Mol Res 2012,11 (3):2641-2651. (共同通訊作者)(IF=0.994)
2013年:
(1) Zhang P., Li C*., Zhu L., Su X., Li Y., Jin C., Li T. De novo assembly of the sea cucumber Apostichopus japonicus hemocytes transcriptome to identify miRNA targets associated with skin ulceration syndrome. PLoS One. 2013, 8(9):e73506. (通訊作者)(IF=3.534)
(2)Zhang P., Lu Y., Li C*., Su X., Wang Z., Jin C., Li Y., Li T. Identification of differential expressed proteins and characterization their mRNA expression in thermally stressed Apostichopus japonicus. Comp. Biochem. Physiol. D. 2013, 8(3):194-200. (通訊作者)(IF=2.823)
(3)Liu Y., Li C*., Su X*., Wang M., Li Y., Li Y., Li T. Cloning and characterization of hemerythrin gene from Sipuncula Phascolosoma esculenta. Genes Genom 2013, 35:95-100. (共同通訊作者) (IF=0.565)
(4)Lu Y., Zhang P., Li C*., Su X., Jin C., Li Y., Li T. Characterisation of immune-related gene expression in clam (Venerupis philippinarum) under exposure to di(2-ethylhexyl) phthalate. Fish Shellfish Immunol. 2013, 34(1):142-146. (通訊作者)(IF=3.034)
(5)Zhang A., Lu Y., Li C*., Zhang P., Su X., Li Y., Wang C., Li T. A small heat shock protein (sHSP) from Sinonovacula constricta against heavy metals stresses. Fish Shellfish Immunol. 2013, 34(6):1605-1610. (通訊作者)(IF=3.034)
(6)Lu Y., Zhang A., Li C*., Zhang P., Su X., Li Y., Mu C., Li T. The link between selenium binding protein from Sinonovacula constricta and environmental pollutions exposure. Fish Shellfish Immunol. 2013, 35(2):271-277. (通訊作者)(IF=3.034)
(7)Lu Y., Li C*., Zhang P., Shao Y., Su X., Li Y., Li T. Two adaptor molecules of MyD88 and TRAF6 in Apostichopus japonicus Toll signaling cascade: molecular cloning and expression analysis. Dev Comp Immunol. 2013, 41(4):498-504. (通訊作者)(IF=3.705)
(8)Zhu L., Li C*., Su X., Guo C., Wang Z., Jin C., Li Y., Li T. Identification and assessment of differentially expressed genes involved in growth regulation in Apostichopus japonicus. Genet Mol Res 2013,12 (3):3028-3037. (通訊作者)(IF=0.85)
(9) 張鵬,李成華*,李曄,蘇秀榕,金春華,李太武. 刺參(Apostichopus japonicus)腐皮綜合癥發(fā)生相關(guān)蛋白的分離與鑒定. 海洋與湖沼。2013, 44(3):741-746. (通訊作者)
(10) Shao Y., Li C*., Ou C*., Zhang P., Lu Y., Su X., Li Y. Li T. Divergent metabolic responses of Apostichopus japonicus suffered from skin ulceration syndrome and pathogen challenge. J Agric Food Chem. 2013, 61(45):10766-10771. (共同通訊作者) (IF=3.107)
(11)Lu Y., Li C*., Zhang P., Wang D., Su X., Jin C., Li Y., Li T. Characterization of two negative regulators of the Toll-like receptor pathway in Apostichopus japonicus: Inhibitor of NF-κB and Toll-interacting protein. Fish Shellfish Immunol. 2013, 35(5):1663-1669. (通訊作者) (IF=3.034)
2014年
(1) 朱琳,郭春陽,王振,李成華*.基于抑制消減雜交識別白化刺參和青刺
參差異表達基因。寧大學(xué)報理工版。2014, 27(1):8-12. (通訊作者)
(2)Zhang P., Li C*., Li Y*., Zhang P., Saho Y., Jin C., Li T. Proteomic identification of differentially expressed proteins in sea cucumber Apostichopus japonicus coelomocytes after Vibrio splendidus infection. Dev Comp Immunol. 2014, 44(2):370-377. (共同通訊作者)(IF=2.815)
(3) Zhang P., Li C*., Shao Y., Chen X., Li Y., Su X., Li T. Identification and characterization of miR-92a and its targets modulating Vibrio splendidus challenged Apostichopus japonicus. Fish Shellfish Immunol. 2014, 38(2):383-385. (通訊作者) (IF=2.674)
(4) Zhang P., Li C*., Zhang P., Jin C., Pan D., Bao Y. iTRAQ-based proteomics reveals novel members involved in pathogen challenge in sea cucumber Apostichopus japonicus. PLoS One. 2014, 9(6):e100492. (通訊作者)(IF=3.234)
(5) Li C*., Chen X., Zhang P., Lu Y., Zhang R. Di-(2-ethylhexyl) phthalate mediates glycolysis and the TCA cycle in clam Venerupis philippinarum. Invert Surviv J. 2014, 11:174-181. (通訊作者)(IF=0.929)
(6) Chen X., Zhang R., Li C*., Bao Y*. Mercury exposure modulates antioxidant enzymes in gill tissue and hemocytes of Venerupis philippinarum. Invert Surviv J. 2014, 11:298-308. (共同通訊作者)(IF=0.906)
2015年:
(1) Zhang X., Zhang P., Li C*., Li Y., Jin C., Zhang W. Characterization of two regulators of the TNF-α signa ling pathway in Apostichopus japonicus: LPS- induced TNF-α factor and baculoviral inhibitor ofapoptosisrepeat-containing 2. Dev Comp Immunol. 2015, 48(1):138-142. (通訊作者)(IF=3.62)
(2)Shao Y., Li C*., Chen X., Zhang P., Li Ye., Li T., Jiang J. Metabolomic responses of sea cucumber Apostichopus japonicus to thermal stresses. Aquaculture. 2015, 435:390-397. (通訊作者)(IF=1.893)
(3)Wang H., Zhang W*., Li C*., Lv Z., Jin C. Identification and characterization of a novel Foxo transcription factors in Apostichopus japonicus. Fish Shellfish Immunol. 2015, 44(1):164-171.(共同通訊作者) (IF=3.025)
(4)張秀梅,李成華*.脂多糖誘導(dǎo)的腫瘤壞死因子(LITAF)生物學(xué)功能研究進展。中國細胞生物學(xué)學(xué)報。2015, 37(4):553-559. (通訊作者)
(5)Lv Z., Li C*., Zhang P., Wang Z., Zhang W., Jin C. miR-200 modulates coelomocytes antibacterial activities and LPS priming via targeting Tollip in Apostichopus japonicas. Fish Shellfish Immunol. 2015, 45(2):431-436.(通訊作者) (IF=3.025)
(6)Lu M., Zhang P., Li C*., Zhang W., Jin C., Han Q. MiR-31 modulates coelomocytes ROS production via targeting p105 in Vibrio splendidus challenged sea cucumber Apostichopus japonicus in vitro and in vivo. Fish Shellfish Immunol. 2015, 45(2):293-299.(通訊作者) (IF=3.025)
(7)Shao Y., Li C*., Che Z., Zhang P., Zhang W., Duan X., Li Y. Cloning and Characterization of two lipopolysaccharide-binding protein/ bactericidal permeability-increasing protein (LBP/BPI) genes from the sea cucumber Apostichopus japonicus with diversified function in modulating ROS production. Dev Comp Immunol. 2015, 52(1):88-97. (通訊作者)(IF=3.62)
(8)Wang H., Shao Y., Li C*., Zhang W., Lv Z., Jin C*. Molecular characterization of two novel molecular chaperones in bacterial-challenged Apostichopus japonicus. Gene. 2015, 570(1):141-147 (共同通訊作者)(IF=2.319)
(9)Lu M., Zhang P., Li C*., Lv Z., Zhang W., Jin C. miRNA-133 augments coelomocyte phagocytosis in bacteria-challenged Apostichopus japonicus via targeting the TLR component of IRAK-1 in vitro and in vivo. Sci. Rep. 2015, 5:12608. (通訊作者)(IF=5.228)
(10)Shao Y., Li C*., Zhang W., Duan X., Li Y., Han Q., Jin C. Three members in JAK/STAT signal pathway from the sea cucumber Apostichopus japonicus: Molecular cloning, characterization and function analysis. Fish Shellfish Immunol. 2015, 46(2):523-536.(通訊作者) (IF=3.025)
(11)陳曉聰,張冉,李成華*,包永波. 菲律賓蛤仔(Venerupis philippinarum)對重金屬Hg2+的富集及相關(guān)生物標(biāo)記物的識別. 海洋與湖沼. 2015, 46(4): 928-935.
(12)Zhang P., Li C*., Zhang R., Zhang W., Jin C., Wang L., Song L. The roles of two miRNAs in regulating the immune response of sea cucumber. Genetics. 2015, 201(4): 1397-1410(IF=4.644
2016年:
(1)Lv Z., Li C., Zhang W., Jin C., Shao Y., Duan X., Han Q. Nemo like kinase negatively regulates NF-κB activation and coelomocytes apoptosis in Apostichopus japonicus. Dev Comp Immunol. 2016, 54(1):109-115. (通訊作者)(IF=3.218)
(2)Zhang W., Liang W., Li C*. Inhibition of marine Vbirio sp. by pyoverdine from Pseudomonas seruginosa PA1. J Hazard Mater. 2016, 302: 217-224. (IF=6.065)
(3)Zhang W., Li C*.Exploiting quorum sensing interfering strategies in gram-negative bacteria for the enhancement of environmental applications.Front. Microbiol.2015, 6:1535.(IF=4.076)
(4)Zhang P., Li C*. Advances on computational methods for identifying the targets of microRNAs: A review. Curr. Bioinform. 2016,11(3):304--309. (通訊作者)(IF=0.600)
(5)Sun X., Lv Z., Li C*., Lu M., Zhang P., Zhang W. Identification and characterization of miR-31 potential targets by RNA-seq. Fish Shellfish Immunol. 2016, 51(1):26-32 (共同通訊作者) (IF=3.148)
(6)Wang H., Li C*., Wang Z., Shao Y., Lv Z., Zhang W. p44/42MAPK and p90RSK modulate thermal stressed physiology response in Apostichopus japonicus. Comp. Biochem. Physiol. B. 2016, 196-197(1):57-66. (通訊作者)(IF=1.757)
(7)Shao Y., Li C*., Zhang W., Wang Z., Lv Z. The first description of complete invertebrate arginine metabolism pathways implies dose-dependent pathogen regulation in Apostichopus japonicus. Sci. Rep. 2016, 6:23783. (通訊作者)(IF=4.259)
(8)Wang Z., Shao Y., Li C*., Lv Z., Wang H., Zhang W., Zhao X. A β-Integrin from sea cucumber Apostichopus japonicus exhibits LPS binding activity and negatively regulates coelomocyte apoptosis. Fish Shellfish Immunol. 2016, 52(1):103-110 (通訊作者) (IF=3.148)
(9)Shao Y., Wang Z., Lv Z., Li C*., Zhang W., Li Y., Duan X. NF-κB/Rel, not STAT5, regulates nitric oxide synthase transcription in Apostichopus japonicus. Dev Comp Immunol. 2016, 61(1):42-47. (通訊作者)(IF=3.218)
(10)Fan W., Ye Y., Chen Z., Shao Y., Xie X., Zhang W., Liu H*., Li C*. Metabolic product response profiles of Cherax quadricarinatus towards white spot syndrome virus infection. Dev Comp Immunol. 2016, 61(1):236-241. (共同通訊作者)(IF=3.218)
(11)Lv Z., Li C*., Shao Y., Zhang W., Wang Z., Wang H. Programmed cell death 4 in bacterially-challenged Apostichopus japonicus: molecular cloning, expression analysis and functional characterization. Mol Immunol. 2016, 75(1):84-91. (通訊作者)(IF=3.236)
(12)Shao Y., Li C*., Zhang W., Duan X., Li Y., Jin C., Xiong J., Qiu Q. Molecular cloning and characterization of four Caspases members in Apostichopus japonicus. Fish Shellfish Immunol. 2016, 55(1):203-211. (通訊作者)(IF=3.148)
(13)Liang W., Zhang C., Liu N., Zhang W*., Han Q., Li C*. Cloning and characterization of Vshppd, a gene inducing haemolysis and immune response of Apostichopus japonicus. Aquaculture. 2016, 464(1):246--252 (共同通訊作者)(IF=2.570)
(14)Shao Y., Li C*., Zhang W., Duan X., Li Y., Qiu Q., Jin C. Cloning and comparative analysis the proximal promoter activities of arginase and agmatinase genes in Apostichopus japonicus. Dev Comp Immunol. 2016, 65(1):299-308. (通訊作者)(IF=3.218)
(15)Li C*., Zhao M., Zhang C., Zhang W., Zhao X., Duan X., Xu W*. miR210 modulates respiratory burst in Apostichopus japonicus coelomocytes via targeting Toll-like receptor. Dev Comp Immunol. 2016, 65(1):377-381. (第一作者,共同通訊作者)(IF=3.218)
(16)Wang Z., Shao Y., Li C*., Zhang W., Duan X., Zhao X., Qiu Q., Jin C. RNA-seq analysis revealed ROS-mediated related genes involved in cadmium detoxification in the razor clam Sinonovacula constricta. Fish Shellfish Immunol. 2016, 57(1):350-361 (通訊作者)(IF=3.148)
(17)Liang W., Zhang S., Zhang W*., Li C*., Han Q. Characterization of functional furVs as a biomarker for detection of aquatic pathogen Vibrio splendidus. Journal of the World Aquaculture Society. 2016, 47(4):577--586 (共同通訊作者)(IF=1.015)
(18)Zhang C., Liang W., Zhang W*., Li C*. Characterization of a metalloprotease involved in Vibrio splendidus infection in the sea cucumber, Apostichopus japonicus. Microb. Pathogenesis. 2016, 101:96--103 (共同通訊作者)(IF=2.009)
(19)Bao Y., Liu X., Zhang W., Cao J., Li W., Li C*., Lin Z*. Identification of a regulation network in response to cadmium toxicity using blood clam Tegillarca granosa as model. Sci. Rep. 2016, 6:35704. (共同通訊作者)(IF=4.259)
(20)Zhao M., Meng C., Xie X., Li C*., Liu H*. Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. Fish Shellfish Immunol. 2016, 59:469-483. (共同通訊作者)(IF=3.148)
(21)車鐘杰,邵銥?zāi)?,李成華*,張衛(wèi)衛(wèi)。刺參殺菌通透性增強蛋白N末端結(jié)構(gòu)域重組蛋白的制備及功能分析。寧大學(xué)報理工版。2016, 29(3):34-38. (通訊作者)
2017年:
(1)Lv M., Chen H., Shao Y., Li C*., Xu W., Zhang W., Zhao X., Duan X. miR-137 modulates coelomocyte apoptosis by targeting 14-3-3ζ in the sea cucumber Apostichopus japonicus. Dev Comp Immunol. 2017, 67:86-96. (通訊作者)(IF=3.218)
(2)Chen H., Lv M., Lv Z., Li C*., Xu W., Zhang W., Zhao X., Duan X., Jin C. Molecular cloning and functional characterization of cathepsin B from the sea cucumber Apostichopus japonicus. Fish Shellfish Immunol. 2017, 60(1):447-457. (通訊作者)(IF=3.148)
(3)Zhang S., Liu N., Liang W., Han Q., Zhang W*., Li C*. Quorum sensing-disrupting coumarin suppressing virulence phenotypes in Vibrio splendidus. Appl Microbiol Biotechnol. 2017, 101(8):3371--3378 (共同通訊作者)(IF=3.420)
(4)Liu N., Zhang S., Zhang W*., Li C*. Vibrio sp. 33 a potential bacterial antagonist of Vibrio splendidus pathogenic to sea cucumber (Apostichopus japonicus). Aquaculture 2017, 470:68--73 (共同通訊作者)(IF=2.570)
(5)Shao Y., Lv Z., Li C*., Zhang W., Duan X., Qiu Q., Jin C., Zhao X. Molecular cloning and functional characterization of theta class glutathione S-transferase from Apostichopus japonicas. Fish Shellfish Immunol. 2017, 63:31-39. (通訊作者)(IF=3.148)
(6)Shao Y., Li C*., Xu W., Zhang P., Zhang W., Zhao X. miR-31 links lipid metabolism and cell apoptosis in bacteria-challenged Apostichopus japonicus via targeting CTRP9. Front. Immunol. 2017, 8: 263 (通訊作者)(IF=6.429)
(7)Zhang Z., Lv M., Shao Y., Qiong Q., Zhang W., Duan X., Li Y., Li C*. Microsomal glutathione transferase 1 attenuated ROS-induced lipid peroxidation in Apostichopus japonicus. Dev Comp Immunol. 2017, 73:79-87. (共同通訊作者)(IF=3.218)
(8)Chen H., Lv M., Lv Z., Li C*., Zhang W., Zhao X., Duan X., Jin C., .Xiong J., Xu F., Li Y. Divergent roles of three cytochrome c in CTSB-modulating coelomocyte apoptosis in Apostichopus japonicus. Dev Comp Immunol. 2017, 76:65-76. (通訊作者)(IF=3.218)
(9)Zhao X., Duan X., Wang Z., Zhang W., Li Y., Jin C.. Xiong J., Li C*. Comparative transcriptome analysis of Sinonovacula constricta in gills and hepatopancreas in response to Vibrio parahaemolyticus infection. Fish Shellfish Immunol. 2017, 67:523-535. (通訊作者)(IF=3.148)
(10)Lv Z., Wei Z., Zhang Z., Li C*., Shao Y., Zhang W., Zhao X., Li Y., Duan X., Xiong J. Characterization of NLRP3-like gene from Apostichopus japonicus provides new evidence on inflammation response in invertebrates. Fish Shellfish Immunol. 2017, 68(1):114-123. (通訊作者)(IF=3.148)
(11)Lv Z., Zhang Z., Wei Z., Li C*., Shao Y., Zhang W., Zhao X., Xiong J. HMGB3 modulates ROS production via activating TLR cascade in Apostichopus japonicus. Dev Comp Immunol. 2017, 77:128-137. (通訊作者)(IF=3.218)
(12)Shao Y., Lv Z., Chen H., Lv M., Li C*., Zhang W., Li Y., Zhao X., Bao Y*. A novel TNFAIP8 gene mediates L-arginine metabolism in Apostichopus japonicus. Fish Shellfish Immunol. 2017, 69(1):26-34. (共同通訊作者)(IF=3.148)
(13)Lv M., Chen H., Shao Y., Li C*., Zhang W., Zhao X., Jin C., Xiong J. miR-92a regulates coelomocytes apoptosis in sea cucumber Apostichopus japonicus via targeting Aj14-3-3ζ in vivo. Fish Shellfish Immunol. 2017, In press. (通訊作者)(IF=3.148)
(14)Zhang Z., Lv Z., Wei Z., Li C*., Shao Y., Zhang W., Zhao X., Xiong J. Microsomal glutathione transferase 2 modulates LTC4 synthesis and ROS production in Apostichopus japonicus. Mol Immunol. 2017, In press. (通訊作者)(IF=3.236)
(15)Zhang S., Zhang W., Liu N., Song T., Liu H., Zhao X., Xu W., Li C*. Indole reduces the expression of virulence related genes in Vibrio splendidus pathogenic to sea cucumber Apostichopus japonicas. Microb. Pathogenesis. 2017, 111:168-173 (通訊作者)(IF=2.009)
中國海洋與湖沼學(xué)會棘皮動物分會理事,浙江省動物學(xué)會理事,兼副秘書長。
(1) 水產(chǎn)動物免疫生物學(xué),國家自然科學(xué)基金/優(yōu)秀青年科學(xué)基金,31522059,2016.1---2018.12,150.0萬元(主持)
(2) 縊蟶高產(chǎn)、抗逆新品種培育,報浙江省農(nóng)業(yè)新品種選育重大科技專項,2016C02055-9,2016.1---2020.12,450.0萬元,子課題負責(zé)人
(3) miR-31靶向調(diào)控刺參腐皮綜合癥發(fā)生的分子機制研究,國家自然科學(xué)基金/面上項目,41576139,2016.1---2019.12,88.8萬元(主持)
(4) 縊蟶快速生長品系的選育和遺傳學(xué)基礎(chǔ)解析,寧波市市科技局/農(nóng)業(yè)與社會發(fā)展攻關(guān)項目,215C10009,2015.3---2017.3,20.0萬元(主持)
(5) 基于可逆蛋白磷酸化層面上的南移仿刺參應(yīng)答高溫脅迫機制的研究,國家自然科學(xué)基金/面上項目,41276120,2013.1---2016.12,78.0萬元(主持)
(6) 刺參腐皮綜合癥發(fā)生相關(guān)microRNAs的發(fā)掘和表達研究,國家自然科學(xué)基金/青年科學(xué)基金,31101919,2012.1---2014.12,23.0萬元(主持)
(7) 基于miRNA調(diào)控網(wǎng)絡(luò)的刺參腐皮綜合癥發(fā)生機制解析,浙江省杰出青年科學(xué)基金,LR14C190001,2014.1---2016.12,34.0萬元(主持)
(8) 基于高通量轉(zhuǎn)錄組測序的刺參腐皮綜合癥發(fā)生及其早期預(yù)警產(chǎn)品的研發(fā),寧波市科技局/農(nóng)業(yè)與社會發(fā)展攻關(guān)項目,2013C10013,2013.4---2015.3,15.0萬元(主持)
(9) 南移刺參生態(tài)苗種繁育技術(shù)開發(fā)與示范,科技部科技部星火計劃,2011.1---2012.12(主持)
(10)基于miRNA調(diào)控視角的刺參腐皮綜合癥發(fā)生的分子機制,浙江省教育廳中青年學(xué)科帶頭人學(xué)術(shù)攀登項目,2013.6---2015.12,5.0萬元(主持)
(11)基于抑制性消減文庫基礎(chǔ)上的南移養(yǎng)殖刺參良種選育研究,浙江省海水養(yǎng)殖創(chuàng)新團隊自主設(shè)計項目,2011.4---2014.3,7.0萬元(主持)
(12)基于菲律賓蛤仔響應(yīng)模式的DEHP污染物快速預(yù)警系統(tǒng)的研究,浙江省科技廳國際合作項目,2013.1---2015.12,20.0萬元(主持)
(13)基于南移養(yǎng)殖刺參的良種選育與分子標(biāo)記研究,寧波市自然科學(xué)基金,2011.1---2012.12,4.0萬元(主持)
(14)重要海域致病性細菌基因芯片檢測技術(shù)研究開發(fā)與示范,國家海洋局公益性行業(yè)專項,2011.1---2014.12,902.0萬元(第二負責(zé)人)
(1) 李成華、李太武、李曄、蘇秀榕、金春華、鄭忠明、張春丹。南移刺參渾水養(yǎng)殖、加工和良種篩選關(guān)鍵技術(shù)的集成與應(yīng)用,浙江省高等學(xué)??蒲谐晒勔坏泉?,第一完成人。
(2) 基于星蟲和海蜇功能基因和功能蛋白的探究,國家海洋局海洋創(chuàng)新獎二等獎,第三完成人。
(3) 李成華、張蕾、趙建民、蘇秀榕、李太武。菲律賓哈仔免疫基因的克隆與表達研究,2012年寧波大學(xué)青年學(xué)術(shù)創(chuàng)新獎(自然科學(xué)類)二等獎,第一完成人。
(4) 李成華、李慧、蘇秀榕、李太武??O蟶鐵蛋白基因的克隆與表達研究,2012年浙江省自然科學(xué)學(xué)術(shù)獎三等獎,第一完成人。
(5) 李成華,張鵬娟、金春華,李太武,李曄,歐昌榮,張衛(wèi)衛(wèi)。用于刺參腐皮綜合癥早期診斷的分子標(biāo)記物及其擴增產(chǎn)物和
應(yīng)用。發(fā)明專利,專利號:ZL201410209458.8.
(6) 李成華 陳曉聰 金春華 李曄 張衛(wèi)衛(wèi) 韓慶喜。用于檢測環(huán)境污染物DEHP的基因芯片及其制備方法和應(yīng)用。發(fā)明專利,專利號:ZL201510284160.8. 2017.5.3
(7) 李成華 邵銥?zāi)?張衛(wèi)衛(wèi) 車鐘杰 張鵬娟 金春華 李曄 歐昌榮。刺參BPI基因、編碼蛋白及其克隆方法和重組刺參BPI基因工程菌構(gòu)建方法。發(fā)明專利,專利號:ZL201510136343.5 2017.6.27
(8) 李成華,秦松,陳愛琴,夏傳海。一種強抗氧化活性的組合物及其應(yīng)用。發(fā)明專利,專利號:ZL200910255706.1
(9) 李成華,金春華,張安國、鄭岳夫、鄭忠明、李太武、謝碧博。刺參南移吊籠養(yǎng)殖技術(shù)規(guī)范。 寧波市地方標(biāo)準(zhǔn)規(guī)范,DB 3302/T 152—2014
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