高永靜 ，神經(jīng)生物學(xué)專業(yè)博士，碩士研究生導(dǎo)師，教授，航海醫(yī)學(xué)研究所副所長，江蘇特聘教授。1995年畢業(yè)于南通醫(yī)學(xué)院臨床醫(yī)學(xué)專業(yè)，并被免試推薦為人體解剖學(xué)專業(yè)碩士研究生（導(dǎo)師：凌樹才教授，現(xiàn)工作于浙江大學(xué)醫(yī)學(xué)院），1999年獲碩士學(xué)位。2004年獲得復(fù)旦大學(xué)神經(jīng)生物學(xué)博士學(xué)位（導(dǎo)師：趙志奇教授）。2006年5-12月在美國圣路易斯華盛頓大學(xué)醫(yī)學(xué)院進(jìn)行博士后工作。2007年1月至2010年10月在美國哈佛大學(xué)醫(yī)學(xué)院工作。2010年11月回國。近五年來，在SCI收錄的期刊上發(fā)表論文近30篇，總影響因子140多，發(fā)表的論文被SCI收錄期刊引用600余次；主持完成國家自然科學(xué)基金一項(xiàng)、江蘇省高校自然科學(xué)研究計(jì)劃項(xiàng)目一項(xiàng)，參與完成多項(xiàng)國家自然科學(xué)基金課題、美國NIH課題。目前主持研究國家自然科學(xué)基金面上項(xiàng)目一項(xiàng)、江蘇省自然科學(xué)基金一項(xiàng)。2004年被評(píng)為江蘇省“青藍(lán)工程”優(yōu)秀青年骨干教師；2005年被評(píng)為南通大學(xué)優(yōu)秀教育工作者，同年獲江蘇省科技進(jìn)步三等獎(jiǎng)、南通市科技進(jìn)步二等獎(jiǎng)一項(xiàng)（排名第二）；2009年入選教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃、2010年獲南通市青年科技獎(jiǎng)；2011年入選江蘇省“333”工程第三層次人才、南通市“226”工程第二層次人才，擔(dān)任中華醫(yī)學(xué)會(huì)疼痛學(xué)分會(huì)基礎(chǔ)組委員會(huì)委員、中華醫(yī)學(xué)會(huì)航海醫(yī)學(xué)分會(huì)青年副主任委員、中國神經(jīng)科學(xué)會(huì)感覺和運(yùn)動(dòng)分會(huì)委員、膠質(zhì)細(xì)胞分會(huì)委員、江蘇省疼痛學(xué)會(huì)青年委員。多次參加國家自然科學(xué)基金項(xiàng)目青年基金項(xiàng)目和面上項(xiàng)目評(píng)審，擔(dān)任《Pain》、《Glia》、《PLoS One》、《Journal of Neuroinflammation》、《Journal of Pain》、《Anesthesia and Analgesia》等近20種疼痛和神經(jīng)科學(xué)領(lǐng)域國際專業(yè)雜志審稿專家。

研究方向：

膠質(zhì)細(xì)胞參與慢性疼痛調(diào)節(jié)的機(jī)制；特殊環(huán)境下疼痛的傳遞和調(diào)制。

研究團(tuán)隊(duì)：

本課題組成員中有具有博士學(xué)位的研究人員3名、具有碩士學(xué)位的青年教師4名、碩士研究生7名。課題組成員年富力強(qiáng)，具有團(tuán)結(jié)協(xié)作精神和對(duì)科研工作的濃厚興趣，是一個(gè)奮發(fā)向上、朝氣蓬勃的集體。

主要通訊作者和第一作者論文

1． Jie Hui, Zhi-Jun Zhang, Xin Zhang, Yan Shen, Yong-Jing Gao*．Repetitive hyperbaric oxygen treatment attenuates complete Freunds adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord．Journal of Pain, accepted, 2013

2． Zhi-Jun Zhang, Yu-Lin Dong, Ying Lu, Zhi-Qi Zhao, Yong-Jing Gao*．Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain．Journal of Neuroinflammation．2012, July 9, 9:136

3． Zhi-Jun Zhang, Lin-Xia Zhao, De-Li Cao, Xin Zhang, Yong-Jing Gao*, Chunlin Xia． Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells．Cellular and Molecular Neurobiology．2012 Aug;32(6):1003-1010

4． Feng-Li Chen, Yu-Lin Dong, Zhi-Jun Zhang, De-Li Cao, Jie Xu, Jie Hui, Li Zhu, Yong-Jing Gao*．Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model．Brain Research Bulletin, 2012,4;87(1):60-6

5． Ying Lu, Li Zhu, Yong-Jing Gao*．Pain related aversion induced astrocytes activation and proinflammatory cytokines expression in rat anterior cingulate cortex．Brain Research Bulletin．2011, 84(2):178-82．

6． Yong-Jing Gao* and Ru-Rong Ji*．Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia．Journal of Neurochemistry．2010, 115(2):505-14．

7． Yong-Jing Gao*, -activated astrocytesaLing Zhang, Ru-Rong Ji*．Spinal injection of TNF- produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1 to induce sensitization of dorsal horn neurons．Glia．2010,58(15):1871-80.

8． Yong-Jing Gao*, Ru-Rong Ji*．Targeting Astrocyte Signaling for Chronic Pain Management．Neurotherapeutics．2010, 7(4):482-93

9． Yong-Jing Gao*, Ru-Rong Ji*．Chemokines, neuronal-glial interactions, and central processing of neuropathic pain．Pharmacology and Therapeutics．2010, 126(1):56-68

10．Yong-Jing Gao*, Zhen-Zhong Xu, Yen-Chin Liu, Yeong-Ray Wen, Isabelle Decosterd, Ru-Rong Ji*． The c-Jun N-terminal Kinase 1 (JNK1) in spinal astrocytes mediates bilateral mechanical allodynia under a persistent inflammatory pain condition．Pain, 2010,148:309-319

11．Yong-Jing Gao, Ling Zhang, Omar Abdel Samad, Marc R．Suter, Kawasaki Yasuhiko, Zhen-Zhong Xu, Jong-Yeon Park, Anne-Li Lind, Qiufu Ma, Ru-Rong Ji．JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain．Journal of Neuroscience, 2009, 29(13):4096–4108

12．Hong Cao*, Yong-Jing Gao*,Wen-Hua Ren, Ting-Ting Li, Kai-Zheng Duan, Yi-Hui Cui, Xiao-Hua Cao, Zhi-Qi Zhao, Ru-Rong Ji, Yu-Qiu Zhang．Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain．Journal of Neuroscience, 2009,29(10):3307–3321 (*Equal contribution)

13．Yong-Jing Gao, Jen-Kun Cheng, Qing Zeng, Zhen-Zhong Xu, Isabelle Decosterd, Xiaoyin Xu, Ru-Rong Ji．Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model． Experimental Neurology, 2009, 219:146–155

14．Yong-Jing Gao*, Ru-Rong Ji*．c-Fos or pERK, Which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? The Open Pain Journal, 2009, 2, 11-17

15．Yong-Jing Gao, Ru-Rong Ji．Activation of JNK pathway in persistent pain．Neuroscience Letter, 2008,6;437(3):180-3

16．Yan-Gang Sun*, Yong-Jing Gao*, Zhong-Qiu Zhao, Bing Huang, Jun Yin, Gregory A Taylor, Zhou-Feng Chen． Involvement of P311 in the affective, but not in the sensory component of pain．Molecular Pain, 2008, 4:23

17．Zhong-Qiu Zhao*, Yong-Jing Gao*, Yan-Gang Sun, Cheng-Shui Zhao, Robert W．Gereau IV, Zhou-Feng Chen．Central serotonergic neurons are differentially required for opioid analgesia, but not for morphine tolerance and morphine reward．PNAS, 2007, 104(36): 14519–14524 (* Equal contribution)

18．Yong-Jing Gao, Wen-Hua Ren, Zhi-Qi Zhao, Yu-Qiu Zhang．Contributions of the anterior cingulate cortex and amygdala to pain- and fear- conditioned place avoidance in rats． Pain, 2004, 110(1-2):343-53

19．Yong-Jing Gao, Yu-Qiu Zhang, Zhi-Qi Zhao．Involvement of spinal neurokinin-1 receptors in the maintenance but not induction of carrageenan-induced thermal hyperalgesia in the rat．Brain Research Bulletin 2003,61(6):587-93

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